Abstract
This study was designed to evaluate the in vivo anti-oxidative stress potentials of Citrus maxima juice. Thirty six wistar rats were divided into nine groups. Group 1 served as the normal control. Groups 2-5 which served as the protective study groups were treated from day 1 to 14 of experiment, and administered Carbon tetrachloride on days 13 and 14. Groups 6-9 served as the curative study groups and were administered Carbon tetrachloride on days 0 and 1 of the experiment and treated from day 1 to 14. All animals were sacrificed on the 15th day after a 14-16 hour overnight fast and blood sample collected through ocular bleeding for biochemical analyses. Intoxication with Carbon tetrachloride decreased significantly (p>0.05) the activities of the antioxidant enzymes - Superoxide dismutase, Gluthatione peroxidase and Catalase. Administration of CMJ increased non-significantly (p>0.05) the activities of the antioxidant enzymes.
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