Abstract
The spatial organization of interphase chromatin is tightly linked to its biological functions. The intra-chromosomal contact frequencies revealed by Hi-C indicated that there is a fundamental variation in the chromatin organization from species to species and along the developmental stage. In this study, we used two different Hi-C contact maps for Human embryonic stem cell (ESC) and fibroblast (FB) to model distinct spatial organization of chromatin into a Gaussian network model and calculated dynamic functions and rheological response. Our calculation suggests that dynamics of loci in FB is associated with longer range cross-correlation than that of ESC. Furthermore, despite the higher contact frequency, FB chromosome retains smaller loss modulus due to the compartmentalized architecture. We discuss these finding in context of current knowledge of the gene expression and regulation during different stages of cell differentiation.
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