Abstract
To determine the effect of cholestyramine on the absorption of digoxin, intragastric3H digoxin was given to 12 rats, 6 of whom were on an 8% cholestyramine diet. The cholestyramine-fed animals showed a significant decrease in stool radioactivity and an increase in urine radioactivity. In another experiment 16 rats had a laparotomy and 8 of these had common bile duct ligation. Half of each group received cholestyramine. In the sham-operated animals there was again decreased stool and increased urine recovery of radioactivity in those receiving cholestyramine. In the bile duct-tied animals, there was decreased stool radioactivity and increased urine radioactivity, and the addition of cholestyramine did not alter the result. The apparent enhancement of digoxin absorption in intact animals by cholestyramine can best be explained by reduction in bile flow due to interruption of the enterohepatic circulation of bile salts by the resin. This may decrease biliary excretion of digoxin.
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