Abstract
A single-walled carbon nanotube (SWCNT) in a field-effect transistor (FET) configuration provides an ideal electronic path for label-free detection of nucleic acid hybridization. The simultaneous influence of more than one response mechanism in hybridization detection causes a variation in electrical parameters such as conductance, transconductance, threshold voltage and hysteresis gap. The channel length (L) dependence of each of these parameters necessitates the need to include them when interpreting the effect of L on the response to hybridization. Using the definitions of intrinsic effective mobility (µe) and device field-effect mobility (µf), two new parameters were defined to interpret the effect of L on the FET response to hybridization. Our results indicate that FETs with ≈300 µm long SWCNT exhibited the most appreciable response to hybridization, which complied with the variation trend in response to the newly defined parameters.
Highlights
Detection of nucleic acids such as deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) is an important issue in the field of biomedical and life science research [1,2]
For all devices, the transfer characteristics showed a change in transconductance, threshold voltage and hysteresis gap, which confirms the contribution of carrier scattering, charge transfer, and charge trapping in detecting hybridization
The single-walled carbon nanotube (SWCNT)-based field-effect transistor (FET) for hybridization detection resulted in a reduced conductance and transconductance, a shift in threshold voltage, and an increase in the hysteresis gap, which varied with channel length
Summary
Detection of nucleic acids such as deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) is an important issue in the field of biomedical and life science research [1,2]. Such FETs showed similar characteristics to those devices with both the channel and junction exposed to cDNA, that is, a reduced Gon, negative shift in Vfth, decrease in gmp and an increase in H (Figure S2a in Supporting Information File 1), which suggests that the channel region contributes significantly to the observed response.
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