Abstract
1. 1. In vitro activities of de novo lipogenesis and lipolysis were compared in isolated adipocytes from male and castrated large white pigs. 2. 2. Castration increased fat cell size and de novo lipogenesis in both subcutaneous and perirenal adipocytes. Lipogenesis was higher in perirenal than in subcutaneous sites. 3. 3. Basal lipolysis was not modified by castration. Addition of theophylline and adenosine deaminase increased the basal rate of lipolysis only in male castrates. 4. 4. Castration reduced the isoproterenol-stimulated lipolysis in both adipose tissues. Theophylline and adenosine deaminase partly restored the isoproterenol-stimulated lipolysis presumably via inhibition of cAMP phosphodiesterase activity. 5. 5. Contrary to male pigs, insulin had no significant antilipolytic action in both adipose tissues in castrated pigs.
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