Effect of CaS nanostructures in growth and proliferation of melanoma and benign skin cells in vitro

Abstract

One person dies of melanoma skin cancer every hour according to the American Cancer Society. The Skin Cancer Foundation highlights that melanoma is the most dangerous form of skin cancer. The standard treatment involves the surgical removal of the tumor with follow up treatments depending on the cancer stage. Once skin cancer melanoma metastasizes, it is very difficult to treat. We have extended our earlier work on the use of calcium sulfide nanostructures to skin cancer melanoma in vitro. We studied the effect of CaS nanostructures in the growth and proliferation of the melanoma ATCC CRL‐7637 skin cancer cells as well as the corresponding pre‐control ATCC CRL‐7636 benign cells and control ATCC CRL‐2106. The results were consistent with our previous studies on mammary adenocarcinoma and lung cancer cells where the malign cell growth and proliferation were limited by the addition of CaS nanostructures with no effect on the growth and proliferation of benign cells over a period of 0, 24, 48 and 72 hours. Work in progress addresses the effect of these nanostructures in the cell life cycle.Support or Funding InformationFinancial support from the NIH RISE‐E‐BASE under grant number 1 R25 GM127191‐01 is gratefully acknowledged.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.