Abstract
The effect of succinate-supported calcium uptake on pregnenolone formation by rat decapsulated and capsular adrenal mitochondria, and on 11β-hydroxylation of added DOC in decapsulated adrenal mitochondria, has been studied. In the absence of additional sources of reducing equivalents, calcium uptake inhibited both these reactions, due to competition with transhydrogenase for high-energy intermediates.
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