Abstract
Previously we reported that pretreatment of rats with caffeine did not result in any observable increase in the P-450 hemoprotein content of the liver microsomes. However, the measurement of ethyl isocyanide difference spectra of dithionite reduced microsomes showed a small but definite increase in the 455-nm peak in the caffeinetreated group. There was no significant increase in the 430-nm peak. In this respect, caffeine action resembled that of 3-methylcholanthrene. Caffeine treatment also increased the rate of NADPH-cytochrome P-450 reductase activity. Microsomal enyzme induction by caffeine was not obliterated by adrenalectomy. The preferential increase in the 455-nm peak was more pronounced in the microsomes of the adrenalectomized animal after caffeine pretreatment.
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