Abstract
Effect of Body Weight on Cytokine Response to Anti-tubercular Therapy in Patients with HIV Infection and Tuberculosis
Highlights
Nutrition plays an important role in stimulating the immune response to varied pathogens especially in patients with tuberculosis
Cytokine response to antitubercular therapy is highly variable in patients with HIV infection and Nutrition plays an important role in determining this response Objectives: To study the effect of body mass index in the levels of cytokines IL-10, intensive phase (IP)-10, IL-4 and Interferon- Gamma before and after treatment with anti tuber-cular therapy in patients with HIV infection Material and methods: It is a prospective cross sectional study, with a population of 50 individuals with HIV infection with tuberculosis were studied
The study was conducted on 50 patients with HIV-associated TB (HIV-TB) commencing anti -tubercular therapy (ATT)
Summary
Nutrition plays an important role in stimulating the immune response to varied pathogens especially in patients with tuberculosis. Results: The mean levels of cytokines IFN-Gamma, IP-10, IL-10 and IL-4 in low BMI group before initiation of ATT are 72.62U/l, 8.90pg/ml, 26pg/ml and 1.24pg/ml. The mean levels of cytokines IFN-Gamma, IP-10, IL-10 and IL-4 in normal BMI group before initiation of ATT are 22.32, 4.17, 11.25 and 0.78. WHO recognises Tuberculosis and HIV to be associated with caloric, protein malnutrition, micronutrients deficits and recommends the patients with mild or moderate malnutrition to eat a healthy diet that meets th Recommended Dietary Allowance (RDA) [2]
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