Effect of Biphasic Bone Graft Material (BGM) in combination with autologous platelet-rich fibrin (PRF) on bone regeneration in an odontogenic maxillary cyst: A randomized controlled clinical trial

Abstract

ABSTRACT Objectives: The purpose of this study was to assess the effect of SYMBIOS® biphasic bone graft material (BGM) in combination with autologous platelets rich fibrin (PRF) on the bone regeneration in the treatment of odontogenic maxillary cysts. Materials and methods: A total of twenty eight patients suffering from large maxillary odontogenic cysts were treated by enucleation and were randomly assigned into two groups. Each group was formed of fourteen patients. The bony defects were grafted by a combination of SYMBIOS® and PRF in group (A) and application of SYMBIOS® alone in group (B). Postoperative clinical and radiographic follow-up were performed. Pain and swelling scores were measured using VAS at 6 weeks postoperative follow up, while bone density of the bony defects were measured using cone beam computerized tomography (CBCT) at 9 months post-operative follow up. Results: Accelerated wound healing was observed in all cases without any signs of postoperative complications. On the 9th month post-operatively the bone density was increased by 45.03% in group (A) where is the results of group B. Conclusion: SYMBIOS®/PRF combination accelerated bone healing and improved the quality and quantity of regenerated bone rather than SYMBIOS® alone.