Abstract
In this work, the influence of Batchelor flow on the polymorphic crystallization in a rotating disk (RD) crystallizer was investigated. By regulating crystallization parameters, i.e., the rotation speed, cooling rate, and ethanol fraction, we found that a higher fraction of L-histidine stable Form-A at the induction time and a faster rate of phase transformation could be obtained in the RD crystallizer as compared to previous results in a mixing tank crystallizer. Based on these results, we concluded that the polymorphic crystallization in the RD crystallizer was more effective due to Batchelor flow fluid motion.
Highlights
Polymorphism is of great interest to the pharmaceutical industry due to the distinct properties of polymorphs, including their bioavailability, solubility, and stability [1,2,3]
It was demonstrated that the tI decreased from 112 to 52 min, while the AI % increased from approximately 35% to 76% when the rotation speed increased from 300 to 1500 rpm
It is indicated that the tI decreased from 108 to 48 min, and the AI % increased from 17% to 71% when the ethanol fraction was decreased from 50 to 0 vol%
Summary
Polymorphism is of great interest to the pharmaceutical industry due to the distinct properties of polymorphs, including their bioavailability, solubility, and stability [1,2,3]. Polymorphic crystallization plays a critical role in harvesting desired polymorphs for pharmaceutical applications. Previous studies on polymorphism in the crystallization process have demonstrated that experimental conditions, such as the rotation speed, supersaturation, solvent, cooling rate, ultrasound, and additives (seeding), are influential parameters affecting the resultant polymorphs in the process of polymorphic crystallization [4,5,6,7,8,9]. Hydrodynamics frequently plays a key role in these parameters during polymorphic crystallization. The stable form of carbamazepine crystals nucleated under the agitated state. Metastable-form crystals were merely generated under the quiescent state [10]. Stirring can improve the nucleation of the stable phase of
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
