Effect of Bajakah (Spatholobus littoralis Hassk.) Extract on Malondialdehyde Serum of Wistar Rats Induced by Streptozotocin

Abstract

Bajakah extract has antioxidant and antidiabetic compounds including phenols, flavonoids, saponins, and tannins. These compounds delay glucose absorption, bind free radicals, and stabilize hydroxides that can suppress oxidative stress conditions. The aim of this study is determined the effect of bajakah extract on serum malondialdehyde in wistar rats induced by streptozotocin. This research is an experimental study using a randomized post-test only control group design. The research sample was 25 male wistar rats ages 2-3 months, grouped into two control groups (K) which were given standard feed (K1) and those given standard feed and induced by streptozotocin (K2) and three treatment groups (P) with bajakah extract intervention as much as 50mg/kgBB (P1), 100mg/kgBB (P2), and 150mg/kgBB (P3). Statistical test using Manova test and Tukey HSD post hoc test. The antioxidant content of the pirated extract is 4.64% phenol, 2.48% flavonoid, 1.06% saponin, and 0.028% tannin. After being given the intervention of bajakah extract for 14 days, the mean serum malondialdehyde levels in groups P1 (2.43±0.33 nmol/L), P2 (1.98±0.50 nmol/L), and P3 (1.79±0.29 nmol/L) were control groups K1 (1.25±0.09 nmol/L) and K2 (3.87±0.70 nmol/L). Based on statistical tests, there were differences in serum malondialdehyde between the control and treatment groups after being given the pirated extract for 2 weeks (p<0.05). The conclusion was obtained that the provision of bajakah extract had antidiabetic and antioxidant activity, was able to reduce serum malondialdehyde in wistar rats with hyperglycemia.