Abstract
Objective Oxidant stress plays an important role in the development of diabetic cardiomyopathy. Previously we reported that Astragalus polysaccharides (APS) rescued heart dysfunction and cardinal pathological abnormalities in diabetic mice. In the current study, we determined whether the effect of APS on diabetic cardiomyopathy was associated with its impact on oxidant stress. Methods Db/db diabetic mice were employed and administered with APS. The hematodynamics, cardiac ultra-structure, apoptosis, and ROS formation of myocardium were assessed. The cardiac protein expression of apoptosis target genes (Bax, Bcl-2, and caspase-3) and oxidation target genes (Gpx, SOD2, t/p-JNK, catalase, t/p-p38 MAPK, and t/p-ERK) were evaluated, respectively. Results APS therapy improved hematodynamics and cardinal ultra-structure with reduced apoptosis and ROS formation in db/db hearts. In addition, APS therapy inhibited the protein expression of apoptosis target genes (Bax, Bcl-2, and caspase-3) and regulated the protein expression of oxidation target genes (enhancing Gpx, SOD2, and catalase, while reducing t/p-JNK, t/p-ERK, and t/p-p38 MAPK) in db/db hearts. Conclusion Our findings suggest that APS has benefits in diabetic cardiomyopathy, which may be partly associated with its impact on cardiac oxidant stress.
Highlights
Diabetes mellitus (DM) is a metabolic disorder with multiple etiology and is one of the three major chronic diseases that affect human health
Astragalus polysaccharides (APS) treatment significantly abolished the negative impact of diabetes on left ventricular hematodynamics and all parameters reached the normal control values (Figure 1)
Astragalus which is the root of Astragalus membranaceus has been widely used for the treatment of heart failure in clinical practice of traditional Chinese medicine
Summary
Diabetes mellitus (DM) is a metabolic disorder with multiple etiology and is one of the three major chronic diseases that affect human health. DM caused by chronic hyperglycemia is associated with both cardiovascular and microvascular complications which is the main cause of disability or death in diabetes [3]. Especially the damage of the diabetic cardiomyopathy hazard is serious [4]. The characteristic cardiomyopathy of ventricular hypertrophy and cardiac dysfunction which can be detected by cardiac tissue Doppler at present as a unique diabetic complication is well recognized [8]. The underlying cause is multifactorial, diabetic cardiomyopathy has been further emphasized. It is a significant cause of morbidity and mortality of cardiovascular complications in diabetic patients worldwide, and a leading cause of end-stage heart failure [9]
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