Abstract
Antisera to bovine LH and rat PRL prepared in rabbits were administered s.c. to intact adult male rats daily for 10 days. Control animals received non-immune rabbit serum. Animals were sacrificed by decapitation without anesthesia 24 hrs. after the last injection. Serum and pituitary LH levels were determined by radioimmunoassay. LH data are expressed in terms of NIAMDD Rat LH-RP-1. Testicular and ventral prostate weights were significantly (p < 0.01) reduced in animals who had received anti-bovine LH serum. There were no effects of anti-bovine LH serum upon body, pituitary or adrenal weights. Pituitary LH concentration was significantly higher in anti-bovine LH serum-treated animals than in control rats (31.2±6.5(SD) μg/mg pituitary vs 22.7±6.8 μg/mg, p<0.02). Serum LH levels were higher in animals who had received anti-bovine LH serum than in control rats. Anti-rat PRL serum had no significant effect upon body, pituitary, testicular, ventral prostate or adrenal weights or upon pituitary LH content or concentration. Serum LH concentrations in anti-rat PRL serum-treated animals were higher than in control animals. Inhibition of gonadotropln activity by anti-LH serum resulted in compensatory increase in LH secretion. Data suggest that anti-PRL serum may also interfere with hypothalamic-pituitary-testicular function.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
