Abstract
1) The diabetogenic dose of alloxan for the albino rat is 150 mg/kg body weight, given in a single dose, subcutaneously. 2) When one third of the diabetogenic dose is employed, albino rats fail to develop diabetes and the pancreatic islet tissue does not show any change revealed by light microscopy. 3) Administration of subdiabetogenic doses of alloxan concurrently with glucose, ACTH or anterior pituitary extract results in structural changes in the pancreatic islet tissue which are reflected by changes in the blood-sugar levels. 4) The histological changes observed in the islet tissue of the pancreases are: degranulation, hyaline degeneration, «hydropic» changes and necrosis. «Hydropic» changes are found to be due to glycogen infiltration of the cells.
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