Abstract
This research aimed to find out whether the combination of Allium sativum, Curcuma mangga, Acorus calamus extracts affect the weight of the uterus, uterus histology and estrogen-progesterone profile of cisplatin-induced rats. This experimental consist of seven treatments and four replications: untreated rats (K-), cisplatin 5mg/Kg BW (K+), dose extract of 50mg/Kg BW (P1), 75mg/Kg BW (P2), 100mg/Kg BW (P3), subur kandungan herbs (P4) and clomiphene citrate 0.9mg/Kg BW (P5). Uterine weight was obtained through weighing. Uterine histological slide were observed by the light microscope, whereas hormonal profile employed by ELISA method. The data were analyzed using the Anova continued with honest significant difference test. The result revealed that cisplatin induction significantly decreased the number of endometrial glands. The administration of extract combination significantly affected the uterine weight, endometrial thickness, number of endometrial glands and estrogen levels of cisplatin-induced rats. The dose of 75mg/Kg BW had the potential to increase the weight of the uterus, endometrial thickness and number of endometrial glands.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.