Abstract
ABSTRACT In 12 patients with hypoparathyroidism, administration of calcium carbonate (10.0–18.0 g/day) was effective in increasing serum calcium by 2.5 to 4.0 mg/100 ml. Tracer studies with 47Ca were performed one or more times in 6 individuals before or after treatment with calcium carbonate or other salts. With these isotope data, and utilizing a 2-compartment open-ended model to describe calcium distribution, compartment sizes and rates of movement of miscible calcium were calculated. The results indicated that increasing serum calcium by use of calcium carbonate in hypoparathyroid patients expanded the size of fast- and slow-exchanging compartments, but decreased calcium interchange between these compartments and reduced calcium deposition in bone. Alkali administration to a single normal individual whose serum calcium was stable also decreased calcium interchange between fast- and slow-exchanging compartments, and, in addition, decreased size of these compartments. The effect of acid salts on calcium...
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