Abstract
The responses of young (150-200 g) and older (275-400 g) rats to starvation-refeeding was studied. In younger rats 2 days of feeding a 65% glucose diet, following 2 days of starvation, caused glucose 6-phosphate dehydrogenase, total liver lipid to reach levels between 2-3 times higher than in rats fed the same diet ad libitum. In older rats the responses of malic enzyme and total liver lipid were less than in the younger rats. The enzyme responses and the responses in total liver lipid were inhibited by 8-azaguanine injections in both age groups. The malic enzyme response in azaguanine—treated rats could be partially restored by exogenous insulin in the young, but not in the older rats. Older rats responded more to dietary sucrose than to dietary glucose. Since older rats appeared to have at least as much serum immunoreactive insulin as did the younger rats, it was concluded that a probable cause of the lesser response in the older rats to starvation-refeeding may be a decreased sensitivity to hormones such as insulin.
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Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
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