Abstract
1. 1. The effect of a single administration of catecholamines on ornithine decarboxylase activity and polyamine biosynthesis in the rat spleen was investigated. 2. 2. Isoproterenol elicited a dose-dependent increase in spleen ODC activity which reached a maximum 4 hr after the administration of the drug. 3. 3. Putrescine content was also found to increase within a few hours, whereas S-adenosylmethionine decarboxylase activity and spermidine and spermine levels did not change significantly. 4. 4. Adrenaline and noradrenaline proved to be even more effective in increasing splenic ODC activity than isoproterenol. 5. 5. α- and β-adrenergic antagonists prevented the ODC increase by catecholamines to a different extent.
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