Abstract
Fusion from within induced by either Newcastle disease or Herpes simplex viruses is completely inhibited by treatment of infected cells with 10 mM 2-deoxy- D -glucose. Hemadsorption to cells infected with Newcastle disease virus is also prevented, and the dose response of inhibition is similar to that for fusion from within. In the case of Newcastle disease virus, fusion from within is prevented by addition of 2-deoxy- D -glucose at any time up to 4 hr after infection; thereafter, fusion becomes rapidly insensitive to addition of the analogue. Fusion from without by high concentrations of Newcastle disease virus particles is, on the other hand, not inhibited by 2-deoxy- D -glucose. These results suggest that inhibition of fusion from within is due to the failure of infected cells to synthesize essential glycoprotein(s) in the presence of the analogue.
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