Abstract
Since Cutting and Tainter1 and Magne, Mayer and Plantefol2 have observed that small quantities of dinitrophenol cause a marked acceleration of the metabolism of animals, it seemed desirable to determine whether this drug accelerates the oxygen uptake of excised tissue.The experiments here reported are a continuation of those given in a previous preliminary report.3 The preparation of the rat tissue slices and the measurement of the oxygen uptake was done as previously described,4 the tissue being suspended in glucose phosphate (pH 7.4) Ringer's solution. Four Warburg vessels were employed in each instance, 2 serving for the control observations. The following experiments were performed. The oxygen uptake of rat liver, kidney and muscle tissue obtained from rats previously injected with dinitrophenol was determined when the tissue was suspended in normal Ringer's solution. Three or more animals were employed in each case. The oxygen uptake of rat liver and kidney tissue obtained from normal animals was als...
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