Abstract
A radioimmunoassay for canine growth hormone (cGH) is described utilizing a sensitive and specific 125I-double antibody system. The assay is capable of detecting concentrations of GH as low as 0.7 ng/ml. Resting venous concentrations were 3.8 ± 0.3 ng/ml. Pentobarbital anesthesia and surgical stress failed to cause a significant increase in these values. However, the administration of L-dopa in a dose of 50 mg/kg iv caused a rapid rise in plasma GH from 1.2 to 21.6 ng/ml within 10 min, with a peak of 25.7 ng/ml at 20 min, and a slow decrease to base line values by 90 min. Continuous administration of L-dopa (a stat intravenous dose of 50 mg/kg followed by a constant infusion of 1 mg/kg/min for 2 hr) resulted in a transient rise in plasma GH concentration. After hypophysectomy, plasma GH concentration fell to less than 2 ng/ml. Thus, L-dopa is a potent stimulus for the secretion of GH in the dog, as it is in man. (Endocrinology 95: 1317, 1974)
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