Abstract
Ipomoea pes-caprae is one of the plants in Indonesia that has the potential as a traditional herbal medicine to treat inflammation. Hence, the objective of this study was to evaluate the effect of I. pes-capraeleaf extract as anti-inflammatory in edema rats induced by 5% egg white solution. The experimental design used was a Completely Randomized Design (CRD) consisted of 5 treatments, each consisted of 5 rats.The treatment consisted of KN = negative control, KP = positive control, giving of 25 mg diclofenac sodium, K 100 = giving 100 mg kg-1body weight (BW) of I. pes-capraeleaf extract , K300 = 300 mg kg-1BW of I. pes-capraeleaf extract, and K500 = 500 mg kg-1BW of I. pes-capraeleaf extract. The anti-inflammatory data obtained were tested statistically with a one-way ANOVA test at 99% confidence level and followed by Duncan's test. The ANOVA test results showed that the giving ofI. pes-capraeleaf extract had a very significant effect (p 0.01) on the percentage of inflammatory, obtained Fcount Ftable, 21.46 4.79 at the level of α = 0.01. The treatment of I. pes-capraeleaf extract of 500 mg kg-1BW had the effect of decreasing the volume of edema with the positive control variable using diclofenac sodium 25 mg. It is concluded that I. pes-capraeleaf extract can be used as an anti-inflammatory by decreasing rat feet edema volume. I. pes-capraeleaf extract has a prospect for non-immunological inflammatory natural drug candidates.
Highlights
Indonesia is a tropical country with many potential plants that still use traditional medicines in their daily lives (Ministry of Trade Republic of Indonesia, 2014)
The objective of this study was to evaluate the effect of I. pes-caprae leaf extract as an anti-inflammatory in edema rats induced by 5% egg white solution
I. pes-caprae leaf extract has a prospect for non-immunological inflammatory natural drug candidates
Summary
Indonesia is a tropical country with many potential plants that still use traditional medicines in their daily lives (Ministry of Trade Republic of Indonesia, 2014). Proving the benefits of traditional medicine through clinical trials supported by immunological research, both through qualitative and quantitative evaluations, need to be encouraged (Subijanto and Diding, 2008). One of the plants in Indonesia that overcomes traditional herbal remedies to deal with inflammation is horse tread Ipomoea pes-caprae L. The I. pes-caprae plant contains active components such as naphthalenone, mellein, eugenol, 4-vinyl-guaiacol. Lipophilic glycosides, 2-methylpropanoic, (2S)methylbutyric, n-hexanoic, n-decanoic, and n-dodecanoic acid (Manigaunha et al, 2011), contain alkaloids, flavonoids, tannins, steroids, acetic acid, melissic acid, myristic acid (Muthalib et al, 2013) The I. pes-caprae plant contains active components such as naphthalenone, mellein, eugenol, 4-vinyl-guaiacol. lipophilic glycosides, 2-methylpropanoic, (2S)methylbutyric, n-hexanoic, n-decanoic, and n-dodecanoic acid (Manigaunha et al, 2011), contain alkaloids, flavonoids, tannins, steroids, acetic acid, melissic acid, myristic acid (Muthalib et al, 2013)
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