Effect and safety of Taohong Siwu decoction combined with moxifloxacin in treatment of chronic pelvic inflammatory disease and its impact on serum inflammatory factors and hemorheology

Abstract

Objective To study the effect and safety of Taohong Siwu decoction combined with moxifloxacin in the treatment of sequelae of pelvic inflammatory disease and its impact on inflammatory factors and hemorheology. Methods 130 cases of sequelae of pelvic inflammatory disease treated at our hospital from March, 2015 to March, 2017 were randomly divided into group A and group B. Group A was treated with moxifloxacin, and the group B with Taohong Siwu decoction and moxifloxacin, for 15 d. After the treatment, the clinical efficacy were analyzed. The levels of serum inflammatory factors such as interleukin-6 (IL-6), interleukin-10 (IL-10), and C-reactive protein (CRP) were detected before and after the treatment. The changes of low shear blood viscosity, high blood viscosity, plasma viscosity, and fibrinogen (FIB) before and after the treatment were detected. All the adverse reactions were recorded during the study. Results After the treatment, the total efficacy was significantly higher in group B than in group A (90.77% vs. 69.23%, P 0.05). Conclusion Taohong Siwu decoction combined with moxifloxacin for sequelae of pelvic inflammatory disease is effective, and can reduce serum inflammatory factors and improve hemorheological changes, so it is an optimal choice for sequelae of pelvic inflammatory disease and is worth for clinical application. Key words: Taohong Siwu decoction; Moxifloxacin; Sequelae of pelvic inflammatory disease; Serum inflammatory factors; Hemorheology