Abstract
Editorial: Why Vaccines to HIV, HCV, and Malaria Have So Far Failed-Challenges to Developing Vaccines Against Immunoregulating Pathogens.
Highlights
Specialty section: This article was submitted to Microbial Immunology, a section of the journal Frontiers in Microbiology
Vaccination is one of the most effective life-saving interventions available in the fight against infectious diseases. As you read this issue of Frontier in Microbiology, scientists around the globe are working toward developing vaccines against diverse infectious diseases, allergies, cancer and autoimmune diseases
If we consider major infectious agents, such as human immunodeficiency virus (HIV), hepatitis C virus (HCV), and Malaria, despite many years of effort, billions of dollars spent and countless animal lives sacrificed, no vaccine is available to protect against these infections
Summary
Specialty section: This article was submitted to Microbial Immunology, a section of the journal Frontiers in Microbiology. Targeting conserved pathogen antigens may help to overcome diversity, these regions are often concealed and/or less accessible to immune effectors. Quinones-Parra and colleagues showed that broadly neutralizing antibodies targeting conserved regions, which developed naturally following the 2009 influenza pandemic, provide hints to the nature of the responses a successful vaccine should elicit (Quinones-Parra et al, 2014).
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