Abstract
reprogramming has been linked to an acquired sensitivity to ferroptosis, thus opening 37 new opportunities to treat tumors unresponsive to other therapies. The activation of 38 ferritinophagy, a specific form of macroautophagy required for the degradation of 39 ferritin, the main cellular iron-storage protein, seems to occur during the early initiation 40 stage of ferroptosis (7). Recent discoveries have highlighted the importance of 41 transferrin trafficking and ferritinophagy, as critical determinants of ferroptosis 42 sensitivity via an increase in the so-called labile iron pool. Qianqian Guo et al., bring 43 us a review on the latest research about iron metabolism disorders in various types of 44 tumors, the functions and properties of iron in ferroptosis and ferritinophagy, and new 45 opportunities for iron-based on treatment methods for tumors, providing more 46 information regarding the prevention and treatment of tumors. In their review, Wen-Jia
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