Abstract
LncRNAs A number of review articles focus on various aspects of lncRNAs in cancer. In particular, Connerty et al. (doi: 10.3389/fonc.2020.00285) discuss the general role of lncRNAs in regulating cellular stress in cancer cells. The authors posit that exploiting lncRNAs-mediated regulatory mechanisms may be a quick and efficient way for cancer cells to overcome oxidative, metabolic, and genotoxic stress, one of the most complex challenges for cancer cells. Other authors discuss Overall, the collection described here highlights the numerous and heterogeneous functions of ncRNAs in various cancers and their therapeutic potential. Nevertheless, many of the described mechanisms appear to be highly tumor type-specific and/or require further characterization at the molecular level. Further studies will help draw a complete picture of the roles of ncRNAs in cancer, to be exploited in the clinics with novel diagnostic and therapeutic approaches. The next 10 years will certainly shed considerable light on the complex RNA expression networks contributing to determine many tumors biological and clinical features.GS and JAS wrote the initial draft. All authors listed have revised and approved the final version for publication.
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