Abstract
Editorial: Advances in the Endocrine Role of the Skeleton
Highlights
In the last two decades, bone tissue has been recognized as an endocrine organ able to regulate the physiology of the whole body
The bone is described as an endocrine organ that secretes many hormones, including FGF-23 (Fibroblast Growth Factor), Osteocalcin and Lipocalin 2, controlling whole body physiology [1]
Experimental data and clinical studies have analyzed the detrimental effect that the perturbation of glucose metabolism has on the skeleton and it has been demonstrated that bone modulates glucose homeostasis
Summary
In the last two decades, bone tissue has been recognized as an endocrine organ able to regulate the physiology of the whole body. From the ancient “vision” of the skeleton as only a scaffold for the body, unexpected functions associated with the bone have been discovered. The bone is described as an endocrine organ that secretes many hormones, including FGF-23 (Fibroblast Growth Factor), Osteocalcin and Lipocalin 2, controlling whole body physiology [1]. The skeleton regulates calcium phosphate balance, energetic metabolism, insulin secretion, male fertility, muscle activity, cognitive functions, and appetite [1,2,3,4].
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