Abstract
Dendritic spine density (DSD) is reduced in postmortem superior temporal gyrus (STG) of schizophrenia (SZ) subjects. DNA methylation (DNAm) may mediate lower DSD given its role in gene expression and studies of global DNAm manipulation demonstrating DSD changes. We previously found that DNAm and DSD correlated at many loci in STG of non-psychiatric control (NPC), but not SZ, subjects. Further, these DNAm-DSD correlations significantly differ between diagnoses at several dendritic spine-associated loci, particularly DLG1, which is altered in expression in SZ and is implicated in DSD regulation.
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