Abstract
Epicardial Adipose Tissue (EAT) has been associated with adverse cardiovascular events in the general population. We studied the association of general adiposity measures (body mass index, waist circumference) and ectopic adipose tissue [visceral adipose tissue (VAT); liver fat (LF); EAT) with prevalent cardiovascular disease (CVD) (prior myocardial infarction, coronary revascularization, stroke, peripheral vascular disease] in 583 HIV-infected men. VAT, EAT, and LF (liver/spleen attenuation ratio < 1.1) were measured by computed tomography. Patients' mean age was 48.5 ± 8.1 years, prior CVD was present in 33 (5.7%) patients. Factors independently associated with CVD on multivariable analyses were age [incidence-rate ratio (IRR) = 1.07, 95% confidence interval (CI): 1.02 to 1.12], smoking (IRR = 2.70, 95% CI: 1.22 to 6.01), Center for Disease Control group C (IRR = 3.09, 95% CI: 1.41 to 6.76), EAT (IRR = 1.13, 95% CI: 1.04 to 1.24, per 10 cm), LF (IRR = 1.17, 95% CI: 1.04 to 1.32), and VAT (IRR = 1.05, 95% CI: 1.00 to 1.10, per 10 cm). Ectopic fat but not general adiposity measures were associated with prevalent CVD in men with HIV.
Highlights
In the general population visceral adipose tissue (VAT) has been demonstrated to correlate with traditional cardiovascular risk factors: total cholesterol, low high-density lipoprotein cholesterol, triglycerides, Apolipoprotein B, blood pressure, insulin resistance, and C-reactive protein.[1,2,3] It is believed that VAT releases free fatty acids into the hepatic circulation, stimulating the release of Apolipoprotein B–containing lipoproteins, reducing insulin sensitivity, and increasing plasma glucose values.[4,5] VAT releases several cytokines that may be involved in the development of atherosclerosis.[6]
We studied the association of general adiposity measures and ectopic adipose tissue [visceral adipose tissue (VAT); liver fat (LF); Epicardial adipose tissue (EAT)) with prevalent cardiovascular disease (CVD)
VAT and EAT were significantly larger in patients with prior CVD compared with those without CVD (P, 0.0001 for both), though the prevalence of LF was not different between groups
Summary
In the general population visceral adipose tissue (VAT) has been demonstrated to correlate with traditional cardiovascular risk factors: total cholesterol, low high-density lipoprotein cholesterol, triglycerides, Apolipoprotein B, blood pressure, insulin resistance, and C-reactive protein.[1,2,3] It is believed that VAT releases free fatty acids into the hepatic circulation, stimulating the release of Apolipoprotein B–containing lipoproteins, reducing insulin sensitivity, and increasing plasma glucose values.[4,5] VAT releases several cytokines that may be involved in the development of atherosclerosis.[6] Epicardial adipose tissue (EAT) shares a common embryological origin with VAT and is metabolically very active, secreting. Received for publication November 2, 2011; accepted January 17, 2012. From the *Department of Medicine and Medical Specialties, University of
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: JAIDS Journal of Acquired Immune Deficiency Syndromes
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
