Abstract
Excess amounts of blood glucocorticosteroids, either exogenous or endogenous, results in Cushing’s syndrome (CS). the current study presents a 45-year-old man, ACTH dependent Cushing’s syndrome. The basal cortisol and urine free cortisol level were significantly suppressed following high dose dexamethasone suppression test and pituitary MRI showed microadenoma with a size of less than 6 mm. After bilateral inferior petrosal sinus sampling, we investigated the ectopic source of ACTH production. The computed tomography revealed a mediastinal lymph node, and the whole body octreotide scan revealed octreotide avid lesion in the medial aspect of the left lung. The patient underwent left lung lobectomy and the pathological study indicated the carcinoid tumor of the left lung.
Highlights
Excess amounts of blood glucocorticosteroids, either exogenous or endogenous, results in Cushing’s syndrome (CS)[1]
This study is going to describe a rare case of CS due to an ectopic Adrenocorticotropic hormone (ACTH) producing tumor presented simulating to Cushing disease according to the clinical and laboratory findings
The srum cortisol level and urine free cortisol (UFC) were suppressed significantly on the high dose dexamethasone suppression test (HDDST), which is more favorable for pituitary cause of hypercortisolism
Summary
Ectopic Acth-Producing Pulmonary Carcinoid: A Rare Case of Simulating the Cushing’s disease. Reza Mohamad hosseinzade Davatgari, Soghra Rabizadeh, Azin Ghamari, Alireza Esteghamati, Manouchehr Nakhjavani1* 1Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran 2Growth and development research center,childrens medical center, Tehran University of Medical Sciences, Tehran, Iran
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