Abstract
Abstract Ectomesenchymal chondromyxoid tumor is a very rare tumor, which mostly occurs in the tongue. Here, we are presenting a case of a 55-year-old man with a swelling in the anterior dorsum of his tongue. The mass was excised and subsequent histopathological examination revealed a subepithelial well-circumscribed mass comprising oval to fusiform tumor cells, arranged in sheets, whorls, and reticular pattern within a prominent chondromyxoid stroma. The tumor cells were positive for glial fibrillary acidic protein, S100, and vimentin, whereas negative for epithelial membrane antigen and p63 on immunohistochemistry. These tumors have to be differentiated from other myxoid lesions, such as oral focal mucinosis, nerve sheath myxoma, soft tissue myxoma, glial choristoma, and ossifying fibromyxoid tumor of soft parts.
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