Abstract
Purpose of the study Antiretroviral (ARV) regimens may be statistically noninferior in clinical trials, but have very different economic outcomes due to differences in costs and adverse event profiles. Given the heavy cost burden of HIV disease, it is important to consider economic issues when selecting an ARV regimen. This study examines the cost and consequences of initiating an ARV regimen including LPV/r or EFV, using data from a recent clinical trial in a previously published model of HIV-disease.
Highlights
Initiating an LPV/r-containing regimen on ARV-naive patients appears cost-effective compared to an EFV-based regimen, when the cost and consequences of lipoatrophy are include
Economic modeling of the combined effects of HIV disease, heart disease and lipoatrophy based on ACTG 5142 trial data
Abstracts of the Ninth International Congress on Drug Therapy in HIV Infection Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1758-2652-11-S1-info.pdf
Summary
Economic modeling of the combined effects of HIV disease, heart disease and lipoatrophy based on ACTG 5142 trial data. Address: 1Medical University of South Carolina, Charleston, USA, 2Abbott Health Economics and Outcomes Research, Abbott Park, USA, 3Abbott GmbH & Co, Ludwigshafen, Germany, 4Abbott Laboratories, North Chicago, USA, 5University of Pittsburg, Pittsburg, USA and 6University of California at San Diego, San Diego, USA. Published: 10 November 2008 Journal of the International AIDS Society 2008, 11(Suppl 1):P312 doi:10.1186/1758-2652-11-S1-P312. Abstracts of the Ninth International Congress on Drug Therapy in HIV Infection Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1758-2652-11-S1-info.pdf
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