Abstract
ABSTRACT ESC (Escitalopram) and ETZ (Etizolam) are essential anti-anxiety medications. This research suggests employing a Green Analytical Quality by Design (AQbD) based HPLC technique to determine ESC and ETZ are environmentally friendly. According to literature, there is currently no published article by this method. Using Phenomenex column C18 containing ethanol and phosphate buffer (60:40 percent v/v) and the flow rate is fixed to be 1 mL/ min, and the detection was carried out at 254 nm the proposed approach can separate ESC and ETZ and their degradation products. Retention times of ESC and ETZ were found to be 3.5 and 6.5 min respectively. This approach was verified and demonstrated linearity ranges from 5–30 μg/mL for ESC, 2–12 μg/mL for ETZ, accuracy, repeatability, and selectivity, with R2 values were 0.9975 and 0.9987 for ESC and ETZ, respectively. The novel method was also evaluated using four different approaches,including other assessment methods: NEMI, GAPI, AGMS, AGREE and it was found to been environment friendly. Based on our results, HPLC techniques with the Green Analytical Performances by the QbD technique for evaluating stability of the drug might be benefit in the development of novel pharmaceutical drugs such as ESC and ETZ.
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