Abstract
Early atheromatous lesions were studied in femoral-popliteal and coronary arteries from a group of subjects aged 50–80 years. Macroscopic quantitation revealed a highly significant difference in the extent of such lesions; the femoral-popliteal arteries showed considerably more early lesions than did the coronaries. Four macroscopic types of early lesions were distinguished, each of them showed a characteristic histologic and histochemical pattern. The development of “preathe-romatous” lipid accumulation were more clearly revealed in the lower limb arteries, whereas coronary arteries displayed a more confused picture. Histochemically the pattern of phospholipid and cholesterol deposition in early femoral-popliteal lesions is the same as in other regions of the arterial tree. The presence of still active and evoluting atherosclerotic lesions in the arteries of old subjects supports the concept of atherosclerosis as a process that is repeatedly “re-awakening” or reactivated during life. This conclusion appears particularly relevant to the femoral-popliteal arteries.
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