Abstract

The Signal Recognition Particle (SRP) mediates the co-translational targeting of proteins destined for the secretory pathway. The particle recognizes a signal peptide as it emerges from the ribosome, temporarily halts translation and mediates docking of the SRP-ribosome-nascent chain complex to a membrane-bound SRP receptor. SRP consists of 7SL RNA and 6 SRP proteins. The ribonucleoprotein can be divided into two functional domains, the Alu domain and S domain. The last decade has yielded a significant amount of structural data on both of the SRP domains.

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