Early reintervention improves outcomes in patients with stroke after carotid endarterectomy: observational study.
Thrombosis of the reconstructed artery after carotid endarterectomy (CEA) may be cause of the postoperative stroke or transitory ischemic attack (TIA). Secondary procedure with the aim to restore carotid flow is required in order to potentially improve patients' condition. Results of such intervention are scarce in the literature. The aim of this study was to assess the outcomes of early reintervention in patients who developed early neurological complications after CEA. A retrospective cohort study was conducted on 36 patients who underwent urgent reoperation with synthetic graft interposition after CEA due to early postoperative neurological deficits. Patient data, including demographics, comorbidities, neurological scores, and surgical details, were collected. Post-revision outcomes were evaluated using the Rankin and NIHSS scores. Patients with intraoperative stroke or those with postoperative stroke who were not operated were excluded from the study. Statistical analyses were performed using McNemar's chi-square and Wilcoxon's signed-rank tests, with multivariate analysis to assess predictive factors for recovery. Out of 36 patients, 94.44% experienced neurological improvement after reoperation. The median Rankin score decreased from 2 to 1 (P<0.001), and the median NIHSS score decreased from 10 to 4 (P<0.001). Significant improvement was observed in arm, leg, and speech deficits, though in patients with consciousness impairments limited recovery was noted. Higher pre-revision Rankin scores and the presence of exulcerated plaques on primary procedure were predictive of poorer outcomes. Detect of early postoperative neurological deficit after CEA is very important. This study showed significant clinical improvement in most patients reoperated immediately with synthetic graft interposition. Further comparison of other potential strategies, including conservative therapy, might bring more data on how to deal with such a difficult complication.
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To evaluate the efficacy and safety of supra-aortic vessels reconstruction within acute period of stroke. Early surgery was performed in 7 patients aged 67±9 years. Revascularization was made after 4.6 days after ischemic stroke on the average (range from 2 to 7 days). Neurological status before and after surgery was assessed using NIHSS scale, mean preoperative score was 3.9±2.7 (0-7). All patients had ischemic brain lesions (4-32 mm, mean 10 mm) unilateral with carotid stenosis or occlusion. Carotid artery stenting was performed in 2 patients, carotid endarterectomy - in 4 patients and stenting of segment I of the left subclavian artery was made in 1 case. There were no mortality and recurrent postoperative ischemic stroke. Complications occurred in two patients: postoperative hematoma and intraoperative transient ischemic attack that developed during CAS after 5 days of a stroke. There was positive neurological dynamics after revascularization: there was almost 2-fold decrease of mean score of neurological deficit (from 3.9±2.7±1.7 to 2). Early surgical prevention of recurrent stroke (up to 7 days) can be performed effectively and safely in carefully selected patients with ischemic stroke (neurological deficit less than 3 Rankin scores and less than 7 NIHSS scores, ischemic lesion dimensions lass than 4 cm). Reconstruction of supra-aortic vessels in acute stage of stroke improves the neurological status and reduces the degree of motor and sensory disorders. However, currently there are no clear criteria for inclusion and exclusion of patients for early revascularization using both degree of neurological deficit and size of ischemic lesion. So our results need to be confirmed by large trials.
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To assess an efficacy and safety of brachiocephalic arteries reconstruction at the acute stage of stroke. Early reconstruction of brachiocephalic arteries was made in 7 patients (mean age 67±9 years). Mean terms of brachiocephalic arteries reconstruction after stroke were 4.6 days (range 2-7 days). Pre- and postoperative neurological state was assessed by NIHSS score (mean preoperative score was 3.9±2.7 in these 7 patients, range 0-7). All patients had ipsilateral cerebral ischemic lesions with stenosis/occlusion of brachiocephalic artery. Their mean dimension was 10 mm (range 4-32 mm). Internal carotid artery stenting was made in 2 patients, carotid endarterectomy - in 4 patients, stenting of the 1st segment of left subclavian artery - in 1 patient. There were no deaths and recurrent postoperative ischemic strokes. Complications developed in 2 patients: postoperative hematoma and intraoperative transient ischemic attack during ICA stenting in 5 days after stroke. There was a positive course of neurological state after brachiocephalic arteries reconstruction: mean score of neurological deficit decreased by almost 2 times (from 3.9±2.7 to 2±1.7). Early surgical prevention (within 7 days after stroke) may be effective and safe in certain patients with ischemic stroke (neurological deficit by Rankin score ≤3 and NIHSS ≤7, ischemic focus dimension less than 4 cm). Brachiocephalic arteries reconstruction early after stroke improves neurological state postoperatively by reducing motor and sensitive disorders. However, at present time there are no clear indications for early revascularization depending on either neurological deficit severity and ischemic focus dimension. So, our data should be confirmed by large trials.
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