Abstract
Rationale Food Allergy is a growing public health concern. There is observational evidence that exposure to food allergens across a disrupted skin barrier can lead to food sensitisation (FS) and food allergy (FA). This mechanism of action has subsequently been proven in murine studies. We sought to ascertain whether a non invasive measurement of skin barrier function at 3 time points in early infancy could predict the development of food sensitisation and allergy in asymptomatic infants enrolled in an unselected prospective birth cohort.
Highlights
Rationale Food Allergy is a growing public health concern
We sought to ascertain whether a non invasive measurement of skin barrier function at 3 time points in early infancy could predict the development of food sensitisation and allergy in asymptomatic infants enrolled in an unselected prospective birth cohort
There was no significant difference between birth Transepidermal Water Loss (TEWL) values in infants with food sensitisation (FS) compared to those without or between those with food allergy (FA) or those without
Summary
Rationale Food Allergy is a growing public health concern. There is observational evidence that exposure to food allergens across a disrupted skin barrier can lead to food sensitisation (FS) and food allergy (FA). This mechanism of action has subsequently been proven in murine studies. We sought to ascertain whether a non invasive measurement of skin barrier function at 3 time points in early infancy could predict the development of food sensitisation and allergy in asymptomatic infants enrolled in an unselected prospective birth cohort
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