Abstract
Hypoxia is closely related to many diseases and often leads to death. Early detection and identification of the hypoxia causes may help to promptly determine the right rescue plan and reduce the mortality. We proposed a new multiparametric monitoring method employing mitochondrial reduced nicotinamide adenine dinucleotide (NADH) fluorescence, regional reflectance, regional cerebral blood flow (CBF), electrocardiography (ECG), and respiration under six kinds of acute hypoxia in four categories to investigate a correlation between the parameter variances and the hypoxia causes. The variation patterns of the parameters were discussed, and the combination of NADH and CBF may contribute to the identification of the causes of hypoxia.
Highlights
Hypoxia is a common pathological phenomenon, accompanying with many diseases, such as neurologic complications,[1] ischemic heart disease,[2] acute renal failure,[3] intestinal ischemia,[4] pulmonary disease,[5] carbon monoxide poisoning,[6] traumatic brain injury,[7] perinatal asphyxia,[8] sudden cardiac death,[9] etc
We have provided experimental evidence that NADH °uorescence can respond to hypoxia several seconds earlier than regional re°ectance, cerebral blood °ow (CBF), electrocardiography (ECG) and respiration do in most hypoxia cases, depending on the way to induce hypoxia.[16]
This articial result was due to the sudden rise of re°ectance at that point, which was probably caused by cerebral cell swelling and water movement.[19]
Summary
Hypoxia is a common pathological phenomenon, accompanying with many diseases, such as neurologic complications,[1] ischemic heart disease,[2] acute renal failure,[3] intestinal ischemia,[4] pulmonary disease,[5] carbon monoxide poisoning,[6] traumatic brain injury,[7] perinatal asphyxia,[8] sudden cardiac death,[9] etc. Rapid and accurate diagnosis in the early stage of hypoxia plays an important role in the treatment and prevention of severe disease development, and determines a patient's prognosis. This is an Open Access article published by World Scientic Publishing Company. Further distribution of this work is permitted, provided the original work is properly cited
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