Abstract
Objective To systematically evaluate the optimal dose of early enteral nutrition support in critically ill patients. Methods Systematic search database including PubMed, Web of science, Scopus, CINAHL, CBM, CNKI. RCTs about early enteral nutrition dose selections in critically ill patients were chosen according to include and exclude criteria by two researchers independently. Cochrane system evaluation manual bias risk assessment was used to evaluate quality of literature. RevMan5.3 Meta analysis software was used to analyze the data. Results A total of 1 571 literatures were retrieved and 8 RCT studies were included, 2 713 subjects in total. Meta analysis results showed that there were statistically significant differences in mechanical ventilation time, incidence of diarrhea, and utilization rate of gastro dynamic drugs between trophic feeding and full feeding (P 0.05). Conclusions Trophic feeding has familiar effects on mortality, length of hospital stay compared to full feeding, but it can help to shorten ICU mechanical ventilation time, improve the gastrointestinal tolerability. Key words: Enteral nutrition; Critical care; Dose; Meta analysis
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