EARLY DISTRIBUTION OF SQUAMOUS PENILE CARCINOMA

Abstract

Introduction: Penile carcinoma is mostly a squamous cell carcinoma (SCC), usually originating from the epithelium of the inner prepuce or the glans. At least one third of the cases can be attributed to HPV-related carcinogenesis. The incidence of penile cancer increases with age, peaking during the sixth decade of life. However, the disease does occur in younger men. Materials and Methods : This abstract features case reports of two patients, aged 44 and 54, respectively, admitted for the first time at the Clinic of Urology at St. Marina University Hospital (Varna, Bulgaria) with similar complaints of non-healing tender lesions in the region of the penis, lasting more than one year. Results: After taking into consideration these complaints, patient no.1 (aged 44) was hospitalized and referred to a CT scan. The CT scan revealed a tumor formation in the corpus of the penis, as well as multiple swollen lymph nodes bilaterally. After the diagnostics an operative intervention - penile amputation and lymphadenectomy was chosen as treatment. Incision biopsy of the operative material revealed a highly differentiated penile squamous cell carcinoma - T2, N0, Mx, G1 (low-grade). Patient no. 2 (aged 54) was admitted into the Clinic of Urology with highly differentiated invasive penile squamous cell carcinoma, diagnosed a month prior. A CT scan of the abdomen and the lesser pelvis was made with the intention of staging the tumor. The scan confirmed an infiltration of the scrotum and the testes. Packages of lymph nodes were visible bilaterally as well as along the iliac blood vessels. Emasculation and lymphadenectomy were chosen as treatment. The incision biopsy confirmed the diagnosis - T3, N3, Mx, G1 (low-grade). Conclusions: The presented case reports prove that the lack of timely consultation with a specialist can lead to radical operative interventions on the male reproductive system, leading to psycho-social discomfort.