Abstract
CARDIAC transplantation has been established as a treatment for end-stage cardiac diseases, however, accelerated graft coronary disease in long-term survivors is still a problem. Selectin-dependent cell adhesion is an initial step in the infiltration of leukocytes to the site of inflammation, which is one of the first pathologic signs of rejection. The inhibition of arterial neointimal formation by E2F decoy after balloon angioplasty in rat carotid injury model was reported. Hemagglutinating virus of Japan (HVJ)-liposome method has been established to increase the efficiency of cellular uptake of E2F decoy. To test the hypothesis that E2F decoy suppresses E-selectin expression in allograft arteries, we performed a single intraluminal delivery of E2F decoy using HVJ-liposome mediated transfer.
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