Abstract
BackgroundRecent studies showed that dyslipidemia could be a critical factor in the progression of cardiovascular disease in systemic lupus erythematosus (SLE). The aim of the present study was to describe the relationship between serum lipid profile and SLE disease activity in young female adults with SLE.MethodsSeventy-one female subjects diagnosed with SLE aged 20~30 years were enrolled. Serum lipid profile including TC, TG, HDL-C, LDL-C, VLDL-C, Apo A, Apo B, and Apo E were evaluated between control and young female SLE patients. Univariate correlation analyses were performed to explore the correlation between serum lipid levels and SLE disease activity.ResultsOur results showed that TG and VLDL-C levels were significantly increased in young female SLE as compared to control, with TC, HDL-C, LDL-C, Apo A, and Apo B significantly reduced. Meanwhile, univariate correlation analyses showed negative correlations between SLE disease activity index and HDL-C, LDL-C, Apo A, and Apo B; with positive correlations between SLE disease activity index and TG and VLDL-C.ConclusionSerum lipid profile was significantly dysregulated in young female SLE patients. Moreover, SLE disease activity was correlated to the serum lipid levels, supporting the notion that the young patients with SLE might also have a higher risk of cardiovascular disease.
Highlights
Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease, which is characterized by the deposition of the immune complex in multiple organs [1]
systemic lupus erythematosus (SLE) disease-related parameters could be taken into consideration when calculating cardiovascular disease risks, and most of the patients with SLE were diagnosed with dyslipidemia, suggesting that dyslipidemia could be a critical factor in the progression of cardiovascular disease in SLE [7,8,9,10]
Once the patients were admitted to the hospital, demographic characteristics were collected; laboratory measurements including dsDNA, total cholesterol (TC), TG, high-density lipoprotein-cholesterol (HDL-C), Low-density lipoprotein-cholesterol (LDL-C), very lowdensity lipoprotein-cholesterol (VLDL-C), apolipoprotein A (Apo A), Apo B and Apo E were done by the diagnostic department and were forwarded to the hospital electronic system
Summary
Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease, which is characterized by the deposition of the immune complex in multiple organs [1]. It has been proved that SLE is associated with increased risk of cardiovascular disease [2], which correlates to elevated mortality in the SLE patients [3]. Chronic activation of the immune system in the patients with SLE could partially result in the development of atherosclerosis [4], the exact mechanisms underlying the progression of cardiovascular disease due to SLE itself were not fully understood. Few studies have investigated the correlation between serum lipid profile and SLE disease activity. Recent studies showed that dyslipidemia could be a critical factor in the progression of cardiovascular disease in systemic lupus erythematosus (SLE).
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