Abstract
BackgroundThe clinical characteristics of diffusion-weighted imaging (DWI) abnormalities after transient neurological symptoms are of great significance for the early diagnosis and urgent intervention of transient ischemic attack (TIA). This study was aimed to investigate the clinical characteristics associated with acute DWI lesions in transient neurological symptoms.MethodsWe retrospectively recruited 302 patients with transient neurological symptoms. According to DWI findings, they were divided into DWI positive and DWI negative group. The clinical characteristics and the TIA-related scores such as ABCD2, ABCD3, ABCD3I, Dawson score, and the Diagnosis of TIA (DOT) score were compared between the two groups. Logistic regression analysis and receiver operating characteristic curves were used to identify the independent factors and compare the predictive value of different TIA scores for acute DWI lesions.ResultsA total of 302 patients were enrolled in this study. The mean age was 61.8 years, and 67.2% were male. We found 89 (29.5%) patients with DWI positivity. Logistic regression analysis showed the characteristic associated with DWI lesions was dysphasia (OR 2.226, 95% CI 1.220–4.062). The area under the curve for Dawson score and the DOT score was 0.610 (95% CI 0.543–0.678) and 0.625 (95% CI 0.559–0.691), respectively.ConclusionWe found that DWI lesions were detected in 29.5% of patients with transient neurological symptoms and were associated with dysphasia. Dawson score and DOT score could have a higher predictability of DWI lesions in patients with transient neurological symptoms.
Highlights
A new tissue-based definition of transient ischemic attack (TIA) is a transient episode of focal neurological deficits consistent with cerebrovascular accident lasting less than 24 h and with the absence of a diffusion-weighted imaging (DWI) lesion detected by MRI [1,2,3,4]
Logistic regression analysis showed that acute DWI lesions were independently correlated with dysphasia (Table 3)
Our result showed that ABCD2, ABCD3, ABCD3I, Dawson score, and Diagnosis of TIA (DOT) score were significantly higher in DWI-positive group
Summary
A new tissue-based definition of transient ischemic attack (TIA) is a transient episode of focal neurological deficits consistent with cerebrovascular accident lasting less than 24 h and with the absence of a diffusion-weighted imaging (DWI) lesion detected by MRI [1,2,3,4]. The Diagnosis of TIA (DOT) score has been proposed [18]. It is a new and internally validated web and mobile app-based diagnostic tool which encompasses both brain and retinal TIA. The clinical characteristics of diffusion-weighted imaging (DWI) abnormalities after transient neurological symptoms are of great significance for the early diagnosis and urgent intervention of transient ischemic attack (TIA). This study was aimed to investigate the clinical characteristics associated with acute DWI lesions in transient neurological symptoms
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