Abstract
Te study included 31 patients with fatal MI type I. Te control group comprised 10 patients of 18-40 age group who died from injuries incompatible with life. Patients with MI were divided into two groups. Group 1 comprised patients who died during the frst 72 hours of MI, group 2 comprised patients who died on days 4‒28. Macrophage infltration in the brain was assessed by immunohistochemical analysis. We used CD68 as a marker for the cells of the macrophage lineage and stabilin-1 as an M2-like macrophage biomarker. In group 1 the number of brain CD68+ macrophages was signifcantly higher than in the control group. In group 2 the intensity of brain CD68+ cells infltration was lower than in group 1 and higher than in the control group. Tere was a small amount of stabilin-1+ macrophages in the brain of healthy people, as well as of patients who died from MI. Tere were no signifcant differences in the number of stabilin-1+ cells between group 1 and group 2. Correlation analysis revealed the presence of positive correlation between the number of CD68 + macrophages in the infarct, peri-infarct, and non-infarct areas of the myocardium and the number of CD68+ macrophages in the brain in patients with MI. Tere were not correlations between the number of CD68 + and stabilin-1+ cells and the presence of diabetes mellitus, history of stroke, history of MI, and pre-infarction angina. Te number of brain CD68+ macrophages signifcantly increased during the frst three days of MI. Te number of brain stabilin-1+ macrophages did not increase and did not differ from the control values. We observed a positive correlation between the number of CD68+ macrophages in the brain and myocardium.
Highlights
В то же время количество stabilin-1‐позитивных М2 макрофагов в головном мозге пациентов, умерших от ИМ, значимо не отличается от контрольных значений и не меняется на протяжении всего периода течения ИМ
Выявлена связь между количеством CD68+ макрофагов в головном мозге и миокарде пациентов, умерших от ИМ 1 типа
Summary
Цель настоящей работы – изучить временную динамику макрофагальной инфильтрации (CD68+ и stabilin-1+) в головном мозге пациентов, умерших от ИМ 1 типа. Количество CD68+ и stabilin-1 макрофагов в головном мозге в 20 полях зрения при 400-кратном увеличении в разные сроки инфаркта миокарда Иммуногистохимическое исследование показало, что в головном мозге здоровых людей (группа 3) присутствовали как CD68+ [4,00 (2,0; 6,0)], так и stabilin 1+ [3,0 (1,0; 5,0)] макрофаги, при этом количество CD68+ и stabilin-1+ макрофагов было небольшим и практически одинаковым У пациентов, умерших в течение первых 3‐х суток ИМ (группа 1), количество CD68+ макрофагов в головном мозге по сравнению со значениями в контрольной группе было выше [63,0 (20,0; 90,0) и 4,00 (2,0; 6,0)] более чем в 15 раз.
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