Abstract

Magnetic resonance imaging's (MRI) potential to monitor interstitial laser photocoagulation (ILP) has been previously demonstrated and is further tested here with improved spatial and temporal resolution. In vivo experiments employed fiber-delivered 1,064 nm light (3.0 W, 150 sec) in six rabbit livers monitored under T1-weighted FSE MRI as 1 image/10 sec and a 3 mm thick 8 cm FOV. Image signal intensities (SI) were compared with temperatures (T) at 7, 10, and 15 mm from the fiber. Data showed 33 degrees C < T < 60 degrees C. SI did not vary inverselinearly with T; changes in the tissue altered the MRI signal interfering with the SI changes due to temperature. MRI cannot map SI-derived temperatures over the entire treatment site. The role of MRI's temperature sensitivity must be coordinated with organ- and dose-specific tissue changes.

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