Abstract
γ-Aminobutyric acid (GABA) receptors are the main receptors supporting inhibition in the central nervous system. These receptors are divided into the ionotropic (GABAA, ion channels) and metabotropic (GABAB, coupled with G proteins) types. Activation of GABAA receptors is the main source of rapid inhibition in the central nervous system. This review addresses dynamic regulation of the delivery of GABAA receptors on formation of inhibitory synapses. The plasticity of inhibitory synapses in regulating the attachment of receptors within them is not discussed. Impairments to the regulation of GABAA receptors has been described in diseases such as epilepsy, anxiety disorders, schizophrenia, and alcoholism. Thus, studies of the biogenesis of GABAA receptors, their dynamic regulation, and their role in the etiology of various diseases are important prerequisites for the development of novel therapeutic strategies.
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