Abstract
AimTo provide a dynamic description of the oral microbial composition in mothers with and without dental caries and their children aging 12-24 months.MethodologyA total of 20 pairs of mothers and their children aged 12 months were included and followed up at 18 and 24 months of age. Ten mothers with dental caries(MEG) and their children(CEG) were in the exposure group, and ten caries-free mothers(MCG) and their children(CCG)in control group. Supragingival plaque biofilm samples were collected and DNA was extracted for bacterial 16S rRNA gene sequencing.ResultsA total of 18 pairs completed follow-ups. At a 3% divergence level, the number of common operational taxonomic units found between the mothers and children increased as the children aged. Proteobacteria, Bacteroidetes, Firmicutes, Fusobacteria, and Actinobacteria accounted for more than 80% phyla of each group. A microbial community structure analysis showed that the differences between mothers and children were significant in all groups except for the MEG24 and CEG24 groups.ConclusionsOral microbiota of children was more like their mothers’ with increasing age, regardless of whether the mothers had dental caries. Mothers with dental caries may have a greater influence on the oral microbiota of children’s than those without dental caries as children age.
Highlights
Dental caries is the most common chronic disease of childhood (Islam et al, 2007)
The oral cavity harbors more than 700 bacterial taxa (Paster et al, 2006), and it has been reported that dental caries involves interactions between the tooth structure and the microbial biofilm formed on the tooth surface (Pitts et al, 2017)
One pair was lost to follow-up at 18 months and one at 24 months due to the nonlocal residence change
Summary
Dental caries is the most common chronic disease of childhood (Islam et al, 2007). Childhood caries (ECC) impair the oral health of children, and affect the general growth and cognitive abilities of children as they age (Martinsjunior et al, 2013). ECC remains the most common chronic childhood disease, accounting for nearly 1.8 billion new Maternal Caries Affects Infants cases globally each year (Vos et al, 2017). The salivary microbiome is dynamic during the first 2 year of life, and is influenced by whether the child was breastfed, and is associated with maternal oral health status (Ramadugu et al, 2021). In any study of the cariogenic mechanisms of microorganisms, the maternal influence is not negligible
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