Abstract
We studied the dynamics of injected contrast enhancement in implanted VX2 tumors in rabbit thigh muscle. We compared two contrast agents Gd-DTPA and NMS60, a novel gadolinium containing trimer of molecular weight 2.1 kd. T 1-weighted spin echo images were acquired preinjection and at 5–60 min after i.v. injection of 0.1 mmol/kg of agent. Dynamic T 1-weighted SPGR images (1.9 s/image) were acquired during the bolus injection. Male NZW rabbits ( n = 13) were implanted with approximately 2 × 10 6 VX2 tumor cells and grew tumors of 28 ± 27 mL over 12 to 21 days. NMS60 showed significantly greater peak enhancement in muscle, tumor rim, and core compared to DTPA in both T 1-weighted and SPGR images. NMS60 also showed delayed peak enhancement in the dynamic scans (compared to Gd-DTPA) and significantly reduced leakage rate constant into the extravascular space for tumor rim (K 21 = 5.1 min −1 vs. 11.5 min −1 based on a 2 compartment kinetic model). The intermediate weight contrast agent NMS60 offers greater tumor enhancement than Gd-DTPA and may offer improved regional differentiation on the basis of vascular permeability in tumors.
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