Abstract
Objective: To investigate the dynamic amplitude of low-frequency fluctuations (dALFFs) in patients with Parkinson's disease (PD) and healthy controls (HCs) and further explore whether dALFF can be used to test the feasibility of differentiating PD from HCs.Methods: Twenty-eight patients with PD and 28 demographically matched HCs underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans and neuropsychological tests. A dynamic method was used to calculate the dALFFs of rs-fMRI data obtained from all subjects. The dALFF alterations were compared between the PD and HC groups, and the correlations between dALFF variability and disease duration/neuropsychological tests were further calculated. Then, the statistical differences in dALFF between both groups were selected as classification features to help distinguish patients with PD from HCs through a linear support vector machine (SVM) classifier. The classifier performance was assessed using a permutation test (repeated 5,000 times).Results: Significantly increased dALFF was detected in the left precuneus in patients with PD compared to HCs, and dALFF variability in this region was positively correlated with disease duration. Our results show that 80.36% (p < 0.001) subjects were correctly classified based on the SVM classifier by using the leave-one-out cross-validation method.Conclusion: Patients with PD exhibited abnormal dynamic brain activity in the left precuneus, and the dALFF variability could distinguish PD from HCs with high accuracy. Our results showed novel insights into the pathophysiological mechanisms of PD.
Highlights
Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by progressive impairment of motor function and widespread non-motor symptoms, which affects patients’ quality of life and is, a significant social burden [1,2,3]
Compared with HCs, significantly increased coefficient of variation (CV) of dALFF was noted in the left precuneus of PD patients (p < 0.001)
We found that the CV of dALFF was positively correlated with disease duration (p < 0.001, r = 0.800) (Figure 1), and no significant correlation was found between dALFF variability and Montreal Cognitive Assessment (MoCA)/Mini Mental Status Examination (MMSE)/Unified Parkinson’s Disease Rating Scale (UPDRS)/Hoehn and Yahr (H-Y) scores (Supplementary Material)
Summary
Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by progressive impairment of motor function and widespread non-motor symptoms, which affects patients’ quality of life and is, a significant social burden [1,2,3]. Magnetic resonance imaging (MRI) has made great contributions in the clinical evaluation of PD [4, 5]. Conventional MRI has been used to exclude secondary parkinsonism caused by neoplasms, vascular parkinsonism, and multiple sclerosis among others. The common imaging features of primary PD include iron deposition and substantia nigra atrophy [6, 7]. It is important to explore novel imaging features that could help effectively identify PD
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